Study of the Absorption of Vitamin E Water-soluble Form (Pegylated) in the Familial Hypocholesterolemia With Chylomicron Retention

• Status: Completed
• Trial end date: 2015-08-01
• Target enrollment: 0
• Participant gender: All

Summary

To evaluate the kinetics of intestinal absorption of vitamin E water-soluble form from the classical lipid-soluble form in a population of patients with intestinal malabsorption (hypocholesterolemias family by retention of chylomicrons).

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Hospices Civils de Lyon
• Treatments: alpha-Tocopherol; Tocopherols; Tocotrienols; Vitamin E; Vitamins

Criteria

Inclusion Criteria:

• Patient suffering from familial hypocholesterolemia by retention of chylomicrons

• Systematically followed in the department of Gastroenterology and Paediatric Nutrition in Women Mother Child's Hospital or in the endocrinology department of GHE (Louis Pradel Hospital);

• During treatment with oral vitamin E;

• over the age of 3 years and weighing over 16 kg at the time of inclusion

• For which there is a signed informed consent from the patient or parents / guardians in the case of a minor patient, and benefit from social security coverage.

Exclusion Criteria:

• Patient with encephalopathy

• Hypersensitivity to the active substance or the excipients of Vedrop

• A suspected allergy to local anaesthetics (including xylocaine)

• Patients who may not be compliant to treatment (psychiatric);

• In case of refusal to participate in the study from the patient and / or parents or legal guardian;

• Patients unable to consent (if patients with encephalopathy)