Study of the Distractibility Syndrome in Patients With Progressive Supranuclear Palsy
Status:
Unknown status
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
The syndrome of distractibility is a behavioral disorder induced by a lesion or a dysfunction
of the frontal lobe. This sign is frequent in patients with progressive supranuclear palsy
(PSP), a neurodegenerative disorder with severe neuronal loss in the prefrontal cortex and
cholinergic systems, in particular in the Meynert basalis nucleus. This could participate in
the occurrence of the distractibility in these patients. The aim of this study is to evaluate
the effect of the donepezil, an anticholinesterase, on the distractibility in PSP patients,
by using oculomotor and neuropsychological assessments.