Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine
Status:
Completed
Trial end date:
2008-05-01
Target enrollment:
Participant gender:
Summary
SEARCH is a randomised, double-blind, multi-centre United Kingdom (UK) trial of 12,064
patients with myocardial infarction (MI) prior to study entry which aims to demonstrate
whether a more intensive cholesterol lowering regimen using 80 mg simvastatin daily produces
a larger and worthwhile reduction in cardiovascular events compared with a standard 20 mg
daily regimen and whether reducing blood homocysteine levels with a daily dose of folic acid
2 mg + vitamin B12 1 mg compared with matching placebo produces a worthwhile reduction in
vascular disease.
Phase:
Phase 3
Details
Lead Sponsor:
University of Oxford
Collaborator:
Merck Sharp & Dohme Corp.
Treatments:
Folic Acid Hydroxocobalamin Simvastatin Vitamin B 12 Vitamin B Complex Vitamins