Study of the Effects of Iron Levels on the Lungs at High Altitude

• Status: Completed
• Trial end date: 2008-11-01
• Target enrollment: 0
• Participant gender: Male

Summary

The study hypothesis is that body iron levels are important in determining the increase in lung blood pressure that occurs in response to low oxygen levels. The purpose of this study is to determine whether this is true at high altitude, where oxygen levels are low.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Oxford
• Collaborator: Universidad Peruana Cayetano Heredia
• Treatments: Ferric Compounds; Ferric Oxide, Saccharated; Iron

Criteria

SLR ARM

Inclusion Criteria:

• sea level natives of lowland ancestry

• generally in good health

• detectable tricuspid regurgitation on echocardiography

Exclusion Criteria:

• any significant medical problem

• known susceptibility to high altitude pulmonary or cerebral oedema

• taking medications or iron supplements

CMS ARM

Inclusion Criteria:

• diagnosis of chronic mountain sickness

• no recent venesection therapy (within 1 year)

• detectable tricuspid regurgitation on echocardiography

Exclusion Criteria:

• any other significant medical problem