Study of the Effects of Iron on Lung Blood Pressure at High Altitude

• Status: Withdrawn
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Body iron levels may be important in determining how the blood pressure in the lungs changes in response to low oxygen levels. At high altitude, where oxygen levels are low, some patients develop elevated lung blood pressure. The investigators hypothesize that, in high altitude residents with elevated lung blood pressure, iron supplementation will cause a reduction in lung blood pressure.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Oxford
• Collaborator: National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov
• Treatments: Ferric Compounds; Ferric Oxide, Saccharated; Iron

Criteria

Inclusion Criteria:

• High altitude natives, currently resident at high altitude

• Pulmonary hypertension (mean pulmonary artery pressure > 25 mmHg)

• Pulmonary artery systolic pressure measurable using Doppler echocardiography

Exclusion Criteria:

• Clinical evidence or history of major co-morbidity

• Recent changes to relevant medications, or taking iron/vitamin supplements