Study of the Effects of an Antidepressant Medication and Placebo on the Brain Functioning of Normal Subjects
Status:
Completed
Trial end date:
2009-02-01
Target enrollment:
Participant gender:
Summary
This study examines the effects of an antidepressant medication and placebo on the brain
functioning of normal subjects. In this study, recordings of brain electrical activity are
being used to detect and monitor the response to treatment with venlafaxine IR (Effexor), a
drug used for the treatment of depression. The intent of this study is to test specific
hypotheses regarding:
1. long-term brain effects of a single course of antidepressant treatment
2. pharmaco-conditioning effects underlying antidepressant tolerance/sensitization
3. brain functional response to initial versus subsequent antidepressant trials in normal
healthy subjects.