Study of the Electrocardiographic Effects of Ranolazine, Dofetilide, Verapamil, and Quinidine in Healthy Subjects
Status:
Completed
Trial end date:
2014-12-01
Target enrollment:
Participant gender:
Summary
This study seeks to compare 4 known QT prolonging drugs versus placebo to determine their
effects on electrophysiological and other clinical parameters. The underlying purpose is to
determine if depolarization and repolarization effects caused by drugs with differing ionic
channel mechanisms can be distinguished from one another, and to gauge the sensitivity and
specificity of novel signal analyses for detection of depolarization and repolarization
changes. Secondarily, to evaluate the exposure response relationship and drug induced effects
on the heart rate biomarker relationship.