Study of the Impact of a Targeted Decolonization of S. Aureus Persistent Carriers
Status:
Recruiting
Trial end date:
2024-10-01
Target enrollment:
Participant gender:
Summary
S. aureus nasal carriage is a well-known risk factor for S. aureus infections in hemodialysis
(HD) patients. Strains of carriage and infections are the same in >80% of cases We recently
shown that persistent carriers of S. aureus, not intermittent ones are at increased risk of
staphylococcal infections in HD. Thanks to a new algorithm developped based on one nasal
sample the determination of carriage status (persistent, intermittent or non-carriers) among
patients is easy. Mupirocin use in HD have been shown to reduce significantly S. aureus
infections however, multiples schedules of decolonization have been proposed to all S. aureus
carriers. To date, there is no national guideline for decolonization of S. aureus in HD. We
showed that only 50% of HD centers in France propose screening and decolonization of S.
aureus carriers. The aim of the study is therefore to evaluate the impact of a targeted
decolonization of S. aureus persistent carriers using mupirocin nasal ointment and
chlorhexidine baths during 5 days on the occurrence of S. aureus infections in HD patients
compared to the absence of decolonization using a randomized open study methodology.