Study of the Safety and Effectiveness of LGH447 and BYL719 in Patients With Relapsed and Refractory Multiple Myeloma
Status:
Completed
Trial end date:
2015-10-28
Target enrollment:
Participant gender:
Summary
This is a Phase Ib/II study with the primary purpose of the Phase Ib part being to estimate
the MTD and/or recommended phase 2 dose (RP2D) of the combination of LGH447 and BYL719 when
administered orally to adult patients with relapsed and refractory multiple myeloma. Once the
MTD and/or RP2D is determined for the combination of LGH447 and BYL719, additional patients
will be enrolled in the Phase II part to determine whether the combination of LGH447 and
BYL719 exhibits improved anti-multiple myeloma activity compared to single agent LGH447. This
trial never made it to the Phase II part of the this trial.