Study on Influence of Leutinizing Hormone (LH) on Oocyte Maturity

• Status: Unknown status
• Trial end date: 2012-11-01
• Target enrollment: 0
• Participant gender: Female

Summary

1. Leutinizing hormone (LH) has been demonstrated to exert variable physiological actions during menstrual cycle at appropriate plasma levels'

2. In early follicular phase,in the requisite range,LH is known to contribute to maturation of oocyte during transition phase from metaphase-1(M1) to metaphase-2 (M2).

3. If during this transition, appropriate level of LH can be maintained either through the use of gonadotropin releasing hormone (GnRH) antagonist if found excessive or supplementation with exogenous LH, if found deficient, maturation process can be enhanced.

4. Further maintenance of suitable combination of recombinant follicle stimulating hormone (rFSH) + rLH can help in realizing higher yield of mature M2 oocytes,with higher probability of establishing clinical pregnancy.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Southern Cross Fertility Centre
• Collaborator: Disha Fertility and Surgical Centre,Indore,India
• Treatments: Cetrorelix; Leuprolide

Criteria

Inclusion Criteria:

• Women aged 18-40 years

• Primary or secondary infertility

• Desire to achieve pregnancy

• Basal FSH <12 mIU/ML

• Moderate to good ovarian reserve (antimullerian hormone (AMH) >1ng/ml, and/ or antral follicle count (AFC)>8 between both ovaries)

• Informed written consent from both partners

• BMI <35 kg/mtr.sq.

• No genetic abnormality

Exclusion Criteria:

• Hormonal preparation taken within 3 month prior to recruitment

• Women with previous poor response to gonadotrophins

• History of previous 3 or more miscarriages

• Women with uncorrected tubal/uterine pathology

• Women opting for assisted procedures like embryo hatching etc.