Study on Left Atrial Function of Atrial Fibrillation After Radiofrequency Ablation With Statin Therapy
Status:
Completed
Trial end date:
2018-08-01
Target enrollment:
Participant gender:
Summary
A total of 120 patients with persistent atrial fibrillation (including continuous and
long-standing persistent atrial fibrillation) and 60 patients with paroxysmal atrial
fibrillation will receive radiofrequency ablation. Patients in each group will be randomly
allocated into the statin treatment group and non-statin treatment group (allocation ratio,
1:1). Left atrial appendage flow velocity of all patients are measured by Transesophageal
Echocardiography(TEE) 24 hours before the operation. Real-time ultrasound examinations of
left atrial function are carried out for all patients before the operation and after the
operation. Blood samples are extracted in all patients before the operation and after the
operation. This study will clarify whether the application of statin drugs can improve
postoperative left atrial function. This study will identify the time course and influence
factors of left atrial recovery of atrial fibrillation after the operation to guide the time
and the degree of anticoagulation and effectively prevent thromboembolic events. At the same
time, biochemical indicators are detected to analyze which indicators are related to the
postoperative recurrence of atrial fibrillation, the incidence of postoperative thrombosis
and the recovery of postoperative left atrial function. Furthermore, this study will
investigate whether the application of statin drugs can improve postoperative left atrial
function by affecting these indicators.