Study on Treatment for Patients With Symptomatic Oral Lichen Planus

• Status: Completed
• Trial end date: 2020-03-20
• Target enrollment: 0
• Participant gender: All

Summary

The primary objective of this study was to compare the therapeutic efficacy of Tacrolimus gel versus an anti-inflammatory mouthwash in an oral solution for the management of patients suffering from symptomatic OLP. The secondary objective was to analyze which one of the two treatments induced a greater risk of developing side effects.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Catania
• Treatments: Tacrolimus

Criteria

Inclusion Criteria:

• age ≥ 18 years;

• clinical diagnosis and histological diagnosis of OLP on the basis of WHO criteria;

• presence of symptoms related to OLP.

Exclusion Criteria:

• presence of systemic conditions that may have affected the study results;

• state of pregnancy or breastfeeding;

• histological signs of dysplasia;

• drugs inducing a lichen response (ACE-inhibitors, β-blockers, etc.);

• treatment of OLP in the six months prior to the start of the programme;

• presence of extraoral lesions (genital, skin and other)

• history of previous immunodeficiency or HIV seropositivity;

• previous allogeneic bone marrow transplantation;

• presence of systemic lupus erythematosus or other autoimmune diseases.