Study on the Correlation Between Intestinal Microecology and Allergic Diseases in Children
Status:
Recruiting
Trial end date:
2023-12-01
Target enrollment:
Participant gender:
Summary
Allergic diseases, including allergic reactions of respiratory tract and skin, are often
triggered by mast cell degranulation mediated by allergen-specific IgE and chronic
inflammation of target organs, which are involved in a variety of immune cells and
inflammatory factors. Recent studies have shown that intestinal immunity is closely related
to immune responses to various diseases. Intestinal microecology influences the occurrence
and regression of various diseases by regulating the growth, differentiation and maturation
of various immune cells. Probiotics are widely used in children with allergies. This study
aims to analyze the correlation between the intestinal microecology of children with
rhinitis/asthma, eczema and urticaria and the clinical manifestations of the patients. By
observing the influence of probiotics intervention on clinical symptoms and changes in
intestinal microecology, the influence of intestinal microecology on children's allergic
diseases was clarified. Study protocol: 1) children with definitive diagnosis of allergic
rhinitis, asthma，atopic dermatitis and chronic urticaria were enrolled, each with 50 cases.
2) collect manure application of 16s rDNA probe hybridization technique to analyze the fecal
flora, and compared with clinical symptoms rating scale and serum sIgE, IgG4 correlation
analysis (3) application of probiotic intervention or conventional drug intervention, again
in 3 months, 6 months after collecting dung is used to detect the intestinal flora in
children with its correlation with clinical symptoms change were observed.
Phase:
Phase 4
Details
Lead Sponsor:
Second Affiliated Hospital, School of Medicine, Zhejiang University
Collaborators:
First People's Hospital Affiliated to Huzhou University The Children's Hospital of Zhejiang University School of Medicine The First Affiliated Hospital with Nanjing Medical University Zhejiang Provincial Hospital of TCM Zibo Central Hospital