Study on the Development of Opioid Induced Hyperalgesia (OIH) After Exposure to Alfentanil

• Status: Completed
• Trial end date: 2010-05-01
• Target enrollment: 0
• Participant gender: Male

Summary

The purpose of this study was to follow a person's response to experimental pain after multiple consecutive exposures to alfentanil or diphenhydramine to see if the person can tolerate the pain more, less, or the same at the end of the study.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Johns Hopkins University
• Collaborator: National Institute on Drug Abuse (NIDA)
• Treatments: Alfentanil; Analgesics, Opioid; Diphenhydramine; Promethazine

Criteria

Inclusion Criteria:

• Age 18-55

• No active medical conditions

• BMI between 20-30

• Able and willing to perform/tolerate pain procedures

• Able to communicate in English

Exclusion Criteria:

• Lifetime substance use disorder, except for alcohol abuse/dependence in remission

• Use of opiates in last 3 months

• Ongoing marijuana use

• Acute or chronic pain

• Neurologic or psychiatric condition known to influence cold pressor testing (peripheral neuropathy, major depression, or schizophrenia)

• Current use of prescribed or over the counter pain medications

• Previous adverse reaction to opiate medications or diphenhydramine

• Use of tobacco or caffeine on study days