Study on the Effect of Prostacyclin Compared to Placebo in Traumatic Brain Injury
Status:
Completed
Trial end date:
2005-12-01
Target enrollment:
Participant gender:
Summary
This study is a prospective consecutive double-blinded randomized study on the effect of
PGI2, prostacyclin (epoprostenol, Flolan®) versus placebo (saline)in patients with severe
traumatic brain injury. All patients with severe traumatic brain injury were eligible for
inclusion. Inclusion criteria: verified traumatic brain injury, Glasgow Coma Score (GCS) at
intubation and sedation of ≤ 8, age 15-70 years, a first-recorded cerebral perfusion pressure
(CPP) of > 10 mm Hg, and arrival within 24 hours after trauma.
Tne primary aim was to evaluate whether treatment with epoprostenol would reduce a
lactate/pyruvate ratio,as measured by cerebral microdialysis after 24 hours of treatment.
A secondary aim was to evaluate the effect of epoprostenol on systemic inflammatory markers,
measured by different cytokines.