Study on the Gut Microbial Mechanism of Negative Symptoms of Schizophrenia
Status:
Not yet recruiting
Trial end date:
2022-09-30
Target enrollment:
Participant gender:
Summary
Negative symptoms are one of the five-dimensional symptoms of patients with schizophrenia,
and medications are not effective in treating negative symptoms. The mechanism of negative
symptoms of schizophrenia is unknown, which may be related to insufficient dopamine function
of the prefrontal cortex. Amisulpride is a D2/D3 receptor antagonist, which can improve
negative symptoms. Intestinal microbes are related to central nervous system mental diseases.
Animal studies have found that changes in the intestinal microflora are related to
schizophrenia. Clinical studies have found that the gut microbes of patients with
schizophrenia are different from those of normal healthy people. Therefore, we are trying to
discover the changes of gut microbes in patients with effective amisulpride treatment, and to
improve the negative symptoms of schizophrenia patients through the intestinal immune system.
The mechanism of brain relationship provides direction, and also provides a new way for the
drug treatment of negative symptoms.