Study to Determine if Taking OTC Non-Steroidal Anti-Inflammatory Affects Eye Pressure in Patients Using Glaucoma Drops

• Status: Completed
• Trial end date: 2008-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The Purpose of This Study is to Determine if Taking an Over the Counter Non-Steroidal Anti-Inflammatory(Ibuprofen)has an Effect on Eye Pressure in Patients using Brimonidine(Alphagan)and Latanoprost(Xalatan) eye drops.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Philadelphia Eye Associates
• Collaborator: Pfizer
• Treatments: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Brimonidine Tartrate; Ibuprofen; Latanoprost

Criteria

Inclusion Criteria:

• Patients with bilateral or unilateral primary open angle glaucoma or ocular hypertension

• An IOP in each eye of greater than 22mm HG after washout of IOP lowering medications

• No worse than 20/200 best corrected visual acuity

• Normal appearing or non-occludable anterior chamber angles

• Discontinuation of current POAG or OH medications before participation in the study.

• Written Informed Consent

Exclusion Criteria:

• Use of any other ocular medications

• Previous ocular surgery or laser therapy within the last three months.

• Systemic treatment with any adrenergic agonist or antagonist, corticosteroid or nonsteroidal anti-inflammatory agents(low dose apsirin will be accepted if dose remains the same for entire study period).

• An age of less than 21,of child bearing age and currently pregnant, considering pregnancy or a nursing mother.

• A history of medical noncompliance or unreliability.

• Presence of uncontrolled hypertension, cardiac arrhythmia, cerebrovascular accident, nasal polyps, bleeding diathesis, peptic ulcer disease, gastritis or known intolerance, contraindication or allergy to any drugs used in the study.

• Lactose Intolerance.