Overview

Study to Determine the Maximum Tolerated Dose (MTD) of PARPi 2X-121 Monotherapy and the MTD of Dovitinib in Combination With 2X-121 in Patients With Advanced Solid Tumors

Status:
Recruiting
Trial end date:
2024-12-01
Target enrollment:
0
Participant gender:
All
Summary
This is a Phase Ib, two-part, multi-center study. In Part 1, the study will evaluate the safety and tolerability, antitumor activity, pharmacokinetics, and determine the maximum tolerated dose (MTD) of 2X-121 monotherapy (at BID regimen) in patients with advanced solid tumors. In Part 2, the study will evaluate safety and tolerability, antitumor activity, pharmacokinetics and determine the MTD of dovitinib when given in combination with the MTD of 2X-121 determined in Part 1.
Phase:
Phase 1
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Allarity Therapeutics
Collaborator:
Amarex Clinical Research
Criteria
Inclusion Criteria:

1. Age 18 years or older.

2. Histologically or cytological documented solid tumor.

3. Available tumor biopsy (most recent) for DRP® analysis.

4. Measurable disease by CT scan or MRI if possible.

5. Performance status of ECOG ≤ 1.

6. Recovered to Grade <1 or baseline from prior surgery or from acute toxicities of prior
radiotherapy, or from treatment with cytotoxic, hormonal or biologic agents.

7. ≥ 2 weeks must have elapsed since any prior surgery or therapy with G-CSF and GM-CSF.

8. Patients with intracranial disease must be on stable or decreased level of steroid
therapy (e.g. dexamethasone) for at least 7 days prior to baseline MRI. Non-enzymatic
inducing anti-epileptic drugs are allowed.

9. Adequate conditions as evidenced by the following clinical laboratory values:

1. Absolute neutrophils count (ANC) ≥ 1500/mm3 (1.5 x 10³/mL)

2. Hemoglobin > 10.0 g/dL

3. Platelets ≥ 100,000/mm3 (≥ 100 x 10⁹/L)

4. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 3 x ULN or
≤5x ULN in presence of liver metastases

5. Serum bilirubin ≤ 1.5 ULN

6. Alkaline phosphatase ≤ 2.5 x ULN

7. Creatinine ≤ 1.5 ULN

8. Blood urea nitrogen (BUN) ≤2X ULN.

10. Life expectancy equal or longer than 3 months.

11. The subject is willing to provide written informed consent to participate in the study
after reading the informed consent form and the information provided and has had the
opportunity to discuss the study with the investigator or designee.

12. The subject is able to communicate satisfactorily with the investigator and to
participate in, and comply with, the requirements of the study.

13. The subject is able to understand the nature of the study and any potential hazards
associated with participating in it.

14. Negative pregnancy test for female subjects of childbearing potential. Women of
childbearing potential (WOCBP) and Women of non-childbearing potential are eligible to
participate. Both women of childbearing potential and women of non-childbearing
potential should use an approved method of birth control and agree to continue to use
this method for the duration of the study (and for 90 days after taking the last dose
of study drug).

Acceptable methods of contraception include abstinence, female subject/partner's use of
hormonal contraceptive (oral, implanted, or injected) in conjunction with a barrier method
(WOCBP only) (e.g., diaphragm, cervical cap, male condom, and female condom and spermicidal
foam, sponges, and film), female subject/partner's use of an intrauterine device (IUD), or
if the female subject/partner is surgically sterile for at least three months before
screening or 2 years post-menopausal at time of screening. All male subjects/partners must
agree to consistently and correctly use a condom for the duration of the study and for 90
days after taking the study drug. In addition, subjects may not donate sperm for the
duration of the study and for 90 days after taking study drug.

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Exclusion Criteria:

1. Concurrent chemotherapy, radiotherapy, hormonal therapy, or other investigational drug
except non-disease related conditions (e.g. insulin for diabetes) during study period.

2. Other malignancy with exception of curative treated non-melanoma skin cancer or
cervical carcinoma in situ within 5 years prior to entering the study.

3. Any active infection requiring parenteral or oral antibiotic treatment.

4. History of coagulation or bleeding disorder or subject currently on therapeutic
anticoagulant medication.

Note: Prophylactic doses of heparin or low molecular weight heparin are allowed.

5. Known HIV positivity.

6. Known active hepatitis B or C.

7. Clinically significant (i.e. active) cardiovascular disease:

1. Stroke within ≤ 6 months prior to day 1

2. Transient ischemic attack (TIA) within ≤ 6 months prior to day 1

3. Myocardial infarction within ≤ 6 months prior to day 1

4. Unstable angina

5. New York Heart Association (NYHA) Class II or greater congestive heart failure
(CHF)

6. Serious cardiac arrhythmia requiring medication.

8. Other medications or conditions, including surgery, that in the Investigator's opinion
would contraindicate study participation for safety reasons or interfere with the
interpretation of study results.

9. Inability to take oral medication, or malabsorption syndrome or any other uncontrolled
gastrointestinal condition (e.g., nausea, diarrhea, or vomiting) that might impair the
bioavailability of 2X-121 and dovitinib.

10. Requiring immediate palliative treatment of any kind including surgery and/or
radiotherapy.

11. Female patients who are pregnant or breast-feeding (pregnancy test with a positive
result before study entry).

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