Study to Evaluate the Effect of Nicotinamide Riboside on Immunity
Status:
Completed
Trial end date:
2018-08-28
Target enrollment:
Participant gender:
Summary
Background:
The immune system controls how the body responds to infection or injury. Researchers want to
see what effect a dietary supplement called nicotinamide riboside (NR) has on the immune
system. A study showed that fasting has a good effect on immune cell health in healthy
people. And when immune cells were exposed to NR they had a similar positive response as with
fasting. Researchers want to see if healthy people have the same effects from NR and fasting,
and if those effects last.
Objectives:
To see if taking nicotinamide riboside will have the same healthy immune system effects as
fasting. To see if these good effects continue even after eating again.
Eligibility:
Healthy volunteers ages 18 - 39 years
Design:
Participants will be screened with medical history, physical exam, and blood tests. Women
will have a urine pregnancy test.
Participants will take 4 pills of either NR or a placebo once a day for 1 week.
On day 6, they will not eat or drink anything.
On day 7, they will have a study visit to give a blood sample before and after eating a meal
at the clinic.
They will also give a urine sample.
Participants will stop taking the pills for 1 2 weeks.
Participants will take either NR or a placebo once a day for 1 week.
They will repeat day 6 and day 7 of the first week.
Participants will get NR once and placebo once, but will not know which they are taking.