Study to Explore the Effect of Mefloquine in Participants With Progressive Multifocal Leukoencephalopathy (PML)
Status:
Terminated
Trial end date:
2010-11-01
Target enrollment:
Participant gender:
Summary
The primary objective of the study was to explore whether mefloquine can delay or stop
progression of progressive multifocal leukoencephalopathy (PML) as measured by JC virus
(human polyomavirus or JCV) deoxyribonucleic acid (DNA) levels in cerebrospinal fluid (CSF).
The secondary objective of the study was to explore whether mefloquine can delay or stop
progression of PML based on neurological deterioration, magnetic resonance imaging (MRI)
measures of brain lesion evolution or the formation of new lesions, and mortality.