Studying Conditioning Regimen In Pediatric Transplantation - AML , SCRIPT-AML
Status:
Recruiting
Trial end date:
2031-12-31
Target enrollment:
Participant gender:
Summary
It is a randomized phase 3 study comparing two conditioning regimens in children with Acute
Myeloid Leukemia, AML, undergoing allogenic stem cell transplantation. The primary aim is to
investigate if a conditioning regimen containing one alkylator (Bu) combined with two
antimetabolites (Clo and Flu) results in superior 2-year acute grade III to IV-free, chronic
non-limited GvHD-free, relapse free survival than a conditioning regimen combining three
alkylating agents (BuCyMel)