Stupp Treatment With Intrathecal Injection of Thiotepa for Glioblastoma With Advanced Spread
Status:
RECRUITING
Trial end date:
2028-04-01
Target enrollment:
Participant gender:
Summary
The goal of this clinical trial is to learn if a combined treatment approach can treat glioblastoma (GBM) with ventricular invasion or meningeal metastasis in adults. The main questions it aims to answer are:
Does the combined treatment of radical radiotherapy, the Stupp regimen (oral temozolomide), and intrathecal injection of thiotepa improve progression-free survival compared to standard treatment alone?
Does the combined treatment improve overall survival compared to standard treatment alone?
Participants will:
* Undergo maximal surgical resection of the tumor
* Receive radical radiotherapy
* Take oral temozolomide according to the Stupp regimen
* Receive intrathecal injections of thiotepa
Phase:
PHASE2
Details
Lead Sponsor:
Second Affiliated Hospital, School of Medicine, Zhejiang University