Sub-dissociative Dose Ketamine Dosing Study

• Status: Completed
• Trial end date: 2019-09-17
• Target enrollment: 0
• Participant gender: All

Summary

Goal is to determine if in adults presenting to the Emergency Department (ED) with moderate to severe acute pain, Ketamine administered at 0.15 mg/kg will provide similar pain relief to Ketamine administered at 0.3 mg/kg, with fewer adverse effects.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Loyola University
• Treatments: Ketamine

Criteria

Inclusion Criteria:

• Adults ages 18-59

• Weight 45 - 115 kg

• Acute abdominal, flank, back, musculoskeletal pain, or a headache

• Onset of pain within 7 days

• Pain score of 5 or more

• Requiring intravenous analgesia

• Hasn't been enrolled in this study previously

Exclusion Criteria:

• Pregnancy

• Breast-feeding

• Altered mental status rendering the patient unable to consent to the study

• Allergy to ketamine

• Unstable vital signs (systolic blood pressure <90 or >180 mm Hg, pulse rate <50 or >150 beats/minute, and respiration rate <10 or >30 breaths/minute)

• History of acute head or eye injury, seizure, intracranial hypertension

• Chronic pain

• Renal or hepatic insufficiency

• Known alcohol or drug use disorder

• Currently under influence of alcohol/opiates

• Acute psychiatric illness