Subconjunctival Bevacizumab Effect on Bleb Vascularity

• Status: Unknown status
• Trial end date: 2011-10-01
• Target enrollment: 0
• Participant gender: All

Summary

Trabeculectomy is an ocular surgery intended to reduce intra-ocular pressure the surgery creates a sub-conjunctival filtering bleb which filters aqueous humor fluid out.

A rather common adverse event of the surgery is increasing vascularity of the conjunctiva overlying the bleb. This leads to adherence of the conjunctiva to the sclera and fibrosis and finally failure of the bleb (and of the surgery) this study intends to demonstrate that post operative subconjunctival bevacizumab injection will reduce incidence of bleb vascularity and ultimately, bleb failure.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Rabin Medical Center
• Treatments: Bevacizumab; Mitomycin; Mitomycins

Criteria

Inclusion Criteria:

• post uneventful trabeculectomy with mitomycin c application during surgery

• adult

Exclusion Criteria:

• usage of 5-fluorouracil in trabeculectomy

• post-operative complications

• ischemic heart disease

• s/p cerebrovascular accident

• allergy to bevacizumab