Subcutaneous Injection of Autologous Adipose Tissue-derived Stromal Vascular Fraction Into the Fingers of Patients With Systemic Sclerosis

• Status: Terminated
• Trial end date: 2019-03-01
• Target enrollment: 0
• Participant gender: All

Summary

Systemic sclerosis (SSc) is an auto-immune orphan disease mainly characterized by an alteration of the microvascular network, and by cutaneous and visceral fibrosis. Hands are frequently affected, as a consequence of ischemic phenomena and cutaneous fibrosis.

. The injection of adipose autologous tissue is a common practice in plastic surgery, and has been known for over a century. Adipose tissue, originally used to increase volume, is also characterized by trophic properties associated to stromal vascular fraction (SVF), which contain multipotent stem cells, capable of tissue repair. Interestingly, some SVF cells can be angiogenic and anti-inflammatory, which could improve damage seen with SSc.

A prior study (the SCLERADEC protocol: ClinicalTrials.gov NCT01813279) has already allowed the safety and tolerance at 6 months of the subcutaneous injection of SVF in the fingers of twelve patients to be proven.

The encouraging results have encouraged us to propose a trial which would bear on a higher number of patients and include a control group.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assistance Publique Hopitaux De Marseille

Criteria

Inclusion Criteria:

• Systemic Sclerosis ( limited or diffuse cutaneous shape)

• Men and women of more than 18 years old

• Patients wishing for a therapeutic alternative

• Functional Disability of the dominant hand authenticated by a functional index of the hand of Cochin functional scale upper to 20

Exclusion Criteria:

• Body mass index (weight in kilograms divided by height in meters squared) lower than 18

• Finger infection (including infected ulcer, ulcer with signs of local inflammation and clinical suspicion of osteitis)

• Contraindication to surgery

• Prescription of a new systemic treatment for SSc in the month before the inclusion

• Subjects infected with HIV, HCV ( hepatitis C virus) , HBV (hepatitis B virus), HTLV ( human T-cell leukemia virus) and syphilis

• Pre-menopausal women of reproductive age, taking no contraceptive method

• Patients receiving immunosuppressive therapy not including corticosteroid therapy < 10 mg/D and methotrexate