Subcutaneous Nitroglycerin to Prevent Radial Artery Occlusion in Children

• Status: Not yet recruiting
• Trial end date: 2025-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The primary objective of the study is to evaluate the vasodilative effect of subcutaneous nitroglycerin to prevent radial arterial occlusion(RAO) after removal of the radial arterial catheter in pediatric patients. The hypothesis of this study is that subcutaneous nitroglycerin will decrease the incidence of radial arterial occlusion after radial arterial catheter removal in pediatric patients by increasing the radial artery size and improving the first-attempt success rate of radial artery cannulation. This is a single-center, double-blind, randomized, placebo-controlled study comparing the effect of subcutaneous nitroglycerin and saline on radial artery cannulation and catheter removal in pediatric patients. Prior to the procedure, each patient will be randomized into either the control arm, saline, or the study arm, nitroglycerin.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Seoul National University Hospital
• Treatments: Nitroglycerin

Criteria

Inclusion Criteria:

• Patients undergoing General anesthesia

• Patients in the Intensive care unit

• Arterial cannulation for hemodynamic monitoring, or multiple blood sample

Exclusion Criteria:

• Unstable vital signs, significant arrhythmia or hypotension, Shock

• High risk of peripheral ischemia

• Skin disease, infection, hematoma, recent cannulation at the radial artery

• History of anaphylaxis to nitroglycerin