Subharmonic Imaging and Pressure Estimation for Monitoring Neoadjuvant Chemotherapy
Status:
Completed
Trial end date:
2018-05-23
Target enrollment:
Participant gender:
Summary
This is a diagnostic accuracy study to evaluate if two novel ultrasound (US) techniques,
quantitative 3D subharmonic imaging (SHI) and Subharmonic Aided Pressure Estimation (SHAPE),
used with an intravenous ultrasound contrast agent (Definity, Lantheus Medical Imaging,
Billerica, MA), can track changes in locally advanced breast cancer (LABC) angiogenesis and
interstitial fluid pressure (IFP), respectively, by studying women undergoing neoadjuvant
chemotherapy before as well as with around 10% and 60% (in part 1) or 30% (in part 2) of the
neoadjuvant chemotherapy treatment delivered and after completion of the neoadjuvant
chemotherapy treatment. Results will be compared to MRI and pathology.
Phase:
N/A
Details
Lead Sponsor:
Sidney Kimmel Cancer Center at Thomas Jefferson University Thomas Jefferson University
Collaborators:
U.S. Army Medical Research and Development Command U.S. Army Medical Research and Materiel Command