Subventricular Zone (SVZ) and Temozolomide in Glioblastoma Multiforme
Status:
Recruiting
Trial end date:
2025-09-01
Target enrollment:
Participant gender:
Summary
In this study patients will be treated with 6 weeks of radiation therapy plus temozolomide
chemotherapy according to the standard of care. However, the radiation treatment plan will be
modified to deliver an higher than routine radiation dose to the subventricular zone which is
an area of the brain that contains stem cells that some scientists believe may contribute to
glioblastoma recurrence. The purpose of the study is to see if the tumor is controlled for a
longer period of time in patients treated with this modified radiation technique than it is
in patients treated with standard radiation therapy plus temozolomide chemotherapy.
Phase:
Phase 2
Details
Lead Sponsor:
Sidney Kimmel Comprehensive Cancer Center Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins