Sugammadex is frequently used to reverse the effects of neuromuscular blocking drugs. The
recommended doses are 2 mg/kg or 4 mg/kg depending upon the depth of neuromuscular blockade.
Clinical studies and experience have suggested that smaller doses may be effective. The
purpose of this observational study is to determine the minimal effective dose of sugammadex
by administering 50 mg every 5 minutes until the train-of-four ratio is 0.9 in a cohort of
cardiac surgery patients, and to determine the duration of action by measuring the
train-of-four every hour for up to 6 hours following reversal.