Sugammadex and Cognitive Function

• Status: Completed
• Trial end date: 2015-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Post operative cognitive dysfunction (POCD) is recognized as a frequent complication after both cardiac and non cardiac surgery, affecting approximately 1/3 of the patients. The aim of this study is to examine the possible effect of the novel reversal agent sugammadex versus neostigmine/ atropine combination on cognitive function of adult patients after elective surgery during the early post operative period as well as at discharge.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Attikon Hospital
• Treatments: Atropine; Neostigmine

Criteria

Inclusion Criteria:

• Patients aged >40 years old

• ASA I-III

• Patients scheduled for elective surgery with general anaesthesia.

Exclusion Criteria:

• Neuro-, vascular-, orthopedic- or cardiac surgery

• Known psychiatric or disease of the CNS

• History of craniotomy

• Receiving tranquillisers or antidepressants on a regular basis pre-operatively

• Alcoholism or drug dependence

• History of stroke

• Refusal of patient

• Inability to read or write

• MMSE < 22 pre-operatively