Overview

Sulfur Colloid SPECT/CT in Measuring Liver Function in Patients With Primary or Metastatic Liver Cancer Undergoing Radiation Therapy or Surgery

Status:
Recruiting

Trial end date:
2025-07-01

Target enrollment:
0

Participant gender:
All

Summary

This pilot trial studies how well single photon emission computed tomography (SPECT)/computed tomography (CT) with technetium Tc-99m sulfur colloid works in measuring liver function in patients with liver cancer that has or has not spread to other place in the body who are undergoing radiation therapy or surgery. Diagnostic procedures, such as sulfur colloid SPECT/CT scans, may measure normal liver tissue before, during and after treatment and help doctors plan better treatment for liver cancer patients.

Phase:

N/A

Accepts Healthy Volunteers?

Details

Lead Sponsor:

University of Washington

Collaborator:

National Cancer Institute (NCI)

Treatments:

Technetium Tc 99m Sulfur Colloid

Criteria

Inclusion Criteria:

- Patients with a diagnosis of hepatocellular carcinoma (HCC), intrahepatic
cholangiocarcinoma, or metastatic liver cancer planned to receive definitive doses of
radiation or surgical resection are eligible

- Measurable hepatic disease and/or presence of vascular tumor thrombosis

- Diagnostic CT or magnetic resonance imaging (MRI) scan within 2 months of study entry

- There are no limits on prior therapy; patients are allowed to have prior systemic
therapy, radiation therapy, radiofrequency ablation, catheter-based therapies, and
surgery; patients are allowed to have concurrent chemotherapy with radiation treatment

- Ability to understand and the willingness to sign a written informed consent document

Exclusion Criteria:

- Patients unable to tolerate a SPECT/CT 99mTc-SC scan

- Patients who are not planning to adhere to the required follow up schedule as outlined
in this protocol

- Pregnant women

- Women of childbearing potential and men who are sexually active and not willing/able
to use medically acceptable forms of contraception

- Patients unable to provide informed consent