Sulindac and Epirubicin in Treating Patients With Metastatic Malignant Melanoma

• Status: Completed
• Trial end date: 2010-05-01
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Sulindac may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as epirubicin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving sulindac together with epirubicin may kill more tumor cells.

PURPOSE: This phase II trial is studying how well giving sulindac together with epirubicin works in treating patients with metastatic malignant melanoma.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Cancer Trials Ireland
• Treatments: Epirubicin; Sulindac

Criteria

DISEASE CHARACTERISTICS:

• Histologically confirmed malignant melanoma

• Metastatic disease

• Tumor block available for resistance marker analysis

• Measurable or evaluable disease

• No active brain metastases except for patients who have undergone successful complete excision of solitary brain metastasis

PATIENT CHARACTERISTICS:

• Karnofsky performance status 80-100%

• ANC > 1 x 10^9/L

• Platelet count > 100 x 10^9/L

• Hemoglobin > 9 g/dL

• Serum bilirubin normal (except in patients with benign congenital hyperbilirubinemia)

• Not pregnant or nursing

• Negative pregnancy test

• Normal cardiac ejection fraction, cardiac wall motion, and ECG

• No active heart disease, including any of the following:

• Myocardial infarction within the past year

• Pericarditis

• Existing hypertension requiring treatment

• No other active serious medical or psychiatric disease

• No prior or concurrent malignancy, other than basal cell carcinoma of the skin , or carcinoma in-situ of the cervix

PRIOR CONCURRENT THERAPY:

• No prior anthracycline or anthracenedione-containing chemotherapy regimen

• No prior cardiac radiotherapy

• No major surgery within the past 2 weeks

• No participation in any clinical trial within the past 4 weeks

• No other concurrent anticancer therapies

• Concurrent bisphosphonates allowed in patients with bony metastases with extra-osseous measurable or evaluable lesions

• No other concurrent experimental medications