Sunitinib and Irradiated Donor Lymphocytes in Treating Patients With Metastatic Kidney Cancer

• Status: Terminated
• Trial end date: 2014-02-22
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Sunitinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Infusing irradiated donor lymphocytes into the patient may help the patient's immune system kill tumor cells. Giving sunitinib together with irradiated donor lymphocytes may kill more tumor cells.

PURPOSE: This phase II trial is studying how well giving sunitinib together with irradiated donor lymphocytes works in treating patients with metastatic kidney cancer.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Rutgers, The State University of New Jersey
• Collaborators: National Cancer Institute (NCI); Rutgers Cancer Institute of New Jersey
• Treatments: Sunitinib

Criteria

DISEASE CHARACTERISTICS:

• Histologically confirmed renal cell carcinoma

• Primary lesion or metastatic site demonstrating clear cell variant with < 25% of any other histology

• Radiographically measurable disease by RECIST criteria

• Initiated treatment with sunitinib malate ≤ 6 weeks ago

• No radiographically detectable brain metastases by MRI or CT scan

• HLA-partially matched related donor available, as determined by serologic and/or DNA typing

• Appropriate HLA match (≥ 2/6 HLA A, B, DR match)

PATIENT CHARACTERISTICS:

• ECOG performance status 0-1

• Absolute neutrophil count > 1,500/mm³

• Platelet count > 100,000/mm³

• Total bilirubin ≤ 2.0 times upper limit of normal (ULN)

• AST ≤ 3.0 times ULN

• Calculated creatinine clearance ≥ 40 mL/min

• Cardiac ejection fraction ≥ 50%

• QTc interval < 500 msec by EKG

• Not pregnant

• Negative pregnancy test

• Fertile patients must use effective contraception

• No known HIV positivity

• None of the following within the past 6 months:

• Myocardial infarction

• Severe/unstable angina

• Coronary/peripheral artery bypass graft

• Symptomatic congestive heart failure

• Cerebrovascular accident or transient ischemic attack

• Pulmonary embolism

• No ongoing ventricular cardiac dysrhythmias ≥ grade 2, according to NCI CTCAE v3.0

• No history of serious ventricular arrhythmia (e.g., ventricular tachycardia > 3 beats in a row)

• No ongoing atrial fibrillation

• No other malignancies within the past 3 years, other than basal cell skin cancer, squamous cell skin cancer, in situ cervical cancer, or ductal or lobular carcinoma in situ of the breast

• No other concurrent serious illness

PRIOR CONCURRENT THERAPY:

• See Disease Characteristics

• No prior systemic therapy for metastatic renal cell carcinoma

• No prior immunotherapy

• No prior VEGF-targeted or mTOR-targeted therapies

• No concurrent cytochrome P450 enzyme-inducing antiepileptic drugs (e.g., phenytoin, carbamazepine, or phenobarbital), St. John's wort, ketoconazole, dexamethasone, dysrhythmic drugs (e.g., terfenadine, quinidine, procainamide, sotalol, probucol, bepridil, indapamide, or flecainide), haloperidol, risperidone, rifampin, grapefruit, or grapefruit juice

• No other concurrent investigational anticancer agents