Sunitinib in Treating Patients With Newly Diagnosed Stage II or Stage III Breast Cancer That Can Be Removed by Surgery

• Status: Completed
• Trial end date: 2011-01-18
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Sunitinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Giving sunitinib before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed.

PURPOSE: This phase II trial is studying how well sunitinib works in treating patients with newly diagnosed stage II or stage IIIA breast cancer that can be removed by surgery.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: NCIC Clinical Trials Group
• Treatments: Sunitinib

Criteria

DISEASE CHARACTERISTICS:

• Histologically confirmed breast cancer

• Newly diagnosed disease

• Stage II-IIIA (T1c, T2, or T3) disease

• Unifocal disease

• Resectable disease

• Tumor must be suitable for multiple biopsies and imaging

• No prior breast cancer

• Hormone receptor status not specified

PATIENT CHARACTERISTICS:

• Male or female

• Menopausal status not specified

• ECOG performance status 0-1

• Absolute granulocyte count ≥ 1,500/mm³

• Platelet count ≥ 100,000/mm³

• Creatinine normal

• Calcium ≤ 3 mmol/L

• Bilirubin normal

• ALT and AST ≤ 2.5 times upper limit of normal

• Not pregnant or nursing

• Negative pregnancy test

• Fertile patients must use effective contraception

• No other malignancies except adequately treated nonmelanoma skin cancer, curatively treated in situ cancer of the cervix, or other solid tumors curatively treated with no evidence of disease for ≥ 5 years

• No QTc prolongation (defined as a QTc interval ≥ 500 msec) or other significant ECG abnormalities

• No history of serious ventricular arrhythmia (ventricular tachycardia or ventricular fibrillation ≥ 3 beats in a row)

• No prior or concurrent NYHA class II-IV cardiovascular disease

• No inadequately controlled hypertension (systolic BP ≥ 140 mm Hg or diastolic BP ≥ 90 mm Hg)

• No myocardial infarction, cardiac arrhythmia, stable or unstable angina, symptomatic congestive heart failure, or coronary/peripheral artery bypass graft or stenting within the past 12 months

• No pulmonary embolism within the past 12 months

• No cerebrovascular accident or transient ischemic attack within the past 12 months

• No serious illness or medical condition that would preclude study compliance including, but not limited to, the following:

• History of significant neurologic or psychiatric disorder

• Active uncontrolled infection

• Serious or nonhealing wound, ulcer, or bone fracture

• No medical condition that could interfere with oral medication intake (e.g., frequent vomiting, malabsorption)

• No history of allergic reactions attributed to compounds with similar chemical composition to sunitinib malate

• No preexisting hypothyroidism unless patient is euthyroid on medication

PRIOR CONCURRENT THERAPY:

• At least 7 days since prior and no concurrent CYP3A4 inhibitors, including the following:

• Azole antifungals (ketoconazole, miconazole)

• Verapamil

• Clarithromycin

• HIV protease inhibitors (indinavir, saquinavir, ritonavir, atazanavir, nelfinavir)

• Erythromycin

• Delavirdine

• Diltiazem

• At least 12 days since prior and no concurrent CYP3A4 inducers, including the following:

• Rifampin

• Phenytoin

• Rifabutin

• Hypericum perforatum (St. John's wort)

• Carbamazepine

• Efavirenz

• Pentobarbital

• Tipranavir

• Phenobarbital

• No prior protein tyrosine kinase inhibitor

• No prior antiangiogenic agent

• No prior hormonal therapy, radiotherapy, chemotherapy, surgery, investigational therapy, or other therapy for breast cancer

• At least 12 days since prior and no concurrent cyclooxygenase-2 inhibitors (e.g., etoricoxib, valdecoxib, celecoxib, dual cyclooxygenase/lipid oxidation, and lumiracoxib)

• No concurrent combination antiretroviral therapy for HIV-positive patients

• No concurrent agents with proarrhythmic potential (e.g., terfenadine, quinidine, procainamide, disopyramide, sotalol, probucol, bepridil, haloperidol, risperidone, indapamide, and flecainide)

• No other concurrent treatment for breast cancer

• No concurrent coumadin-derivative anticoagulants (e.g., warfarin)

• Anticoagulants at ≤ 2 mg/day for prophylaxis of thrombosis allowed

• Low molecular weight heparin allowed provided INR ≤ 1.5