Supplemental oxygen is frequently administered in acutely and critically ill patients,
specifically, it is often administered in trauma patients to avoid arterial hypoxemia and
tissue hypoxia. There is also an increasing focus on potentially deleterious effects of
hyperoxia. Further, the hemodynamic response to hyperoxia in hypovolemia is poorly
understood.
The present study aims to investigate the effects of supplemental oxygen on systemic and
cerebral hemodynamics in simulated hypovolemia in healthy volunteers.