Overview
Suppression of Endogenous Glucose Production by Injectable HDV-Insulin Lispro: A Dose Response Study in Human Subjects With Type 1 Diabetes
Status:
Not yet recruiting
Not yet recruiting
Trial end date:
2026-01-01
2026-01-01
Target enrollment:
0
0
Participant gender:
All
All
Summary
Single-center, double-blind, random-sequence study assessing the HDV dose-response relationship to Endogenous Glucose Production (EGP), Free Fatty Acids (FFA) and Glucose Disposal Rate (GDR) during a euglycemic clamp procedure following overnight stabilization of blood glucose with intravenous insulin (and, if needed intravenous glucose). EGP and GDR will be determined using established radioisotope methodology. The concentration of Hepatic Directed Vesicles (HDV) in the insulin lispro (LIS) infused during the clamp procedure will be varied such that the percentage of HDV-bound LIS will range from 0%, 1%, 10%, and 100%. Each participant will thus undergo four clamp procedures at the four different HDV levels. LIS will be infused at a constant dose (6 mU/m2/min) for each of the four procedures.Phase:
Phase 1Accepts Healthy Volunteers?
Accepts Healthy VolunteersDetails
Lead Sponsor:
University of California, San DiegoCollaborator:
The Leona M. and Harry B. Helmsley Charitable TrustTreatments:
Insulin LisproCriteria
Inclusion Criteria:1. Male or female of age 18 to 65 years, inclusive, who:
2. Has at Screening been diagnosed as T1D for at least 12 months; preference will be
given to potential participants who currently use continuous subcutaneous insulin
infusion (CSII) therapy;
3. Has at Screening C-peptide ≤0.8 ng/mL (single retest allowed);
4. Has at Screening a BMI ≥18.0 kg/m2 and ≤33.0 kg/m2;
5. Has at Screening HbA1c ≥6.5% and ≤8.5 %.
Exclusion Criteria:
1. Has known or suspected allergy to any component of any of the study drugs in this
trial;
2. Is, at Screening, pregnant or breast-feeding, or intends to become pregnant at any
time during the duration of the study;
3. Has, at Screening, as judged by the Site Investigator, a history or current evidence
of any of advance complications of diabetes;
4. Is, at Screening, judged by the Site Investigator to have a current addiction to
alcohol or substances of abuse;
5. Is, at Screening, using one or more drugs that may interfere with the interpretation
of trial results or are known to cause clinically relevant interference with insulin
action, glucose utilization, or recovery from hypoglycemia (e.g., beta blockers,
systemic corticosteroids at pharmacologic doses, cancer chemotherapies);
6. Has, within one (1) month prior to Screening, used either oral anti-diabetic
medication or noninsulin anti-diabetic injection therapies (e.g. SGLT-2 inhibitors,
pramlintide, GLP-1 agonists, etc.);
7. Has, within one (1) month prior to Screening, received any investigational drug;
8. Has, within three (3) months prior to Screening, smoked tobacco or used any smokeless
tobacco or nicotine delivery system (inhaled, oral or buccal);
9. Has at Screening, as judged by the Site Investigator, any condition (intrinsic or
extrinsic) that could reasonably be expected to interfere with trial participation,
confound evaluation of the data, or pose additional risk to adhering to the study
protocol. Examples of such conditions include but are not limited to:
- Clinically significant active disease of the gastrointestinal, cardiovascular,
hepatic, neurological, renal, genitourinary, or hematological systems;
- History of such an illness or disease;
- Diminished mental capacity, psychological or behavioral dysfunction, unwilling or
resistant to protocol requirements, language barriers.