Surgery Followed by Chemotherapy in Treating Young Patients With Soft Tissue Sarcoma

• Status: Completed
• Trial end date: 2009-12-01
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one chemotherapy drug with surgery and/or radiation therapy may kill more tumor cells.

PURPOSE: This randomized phase III trial is studying surgery followed by different regimens of combination chemotherapy given together with radiation therapy and/or additional surgery to compare how well they work in treating patients with soft tissue sarcoma.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Societe Internationale d'Oncologie Pediatrique
• Treatments: Carboplatin; Cyclophosphamide; Dactinomycin; Epirubicin; Etoposide; Ifosfamide; Vincristine

Criteria

DISEASE CHARACTERISTICS:

• Histologically confirmed primary soft tissue sarcoma:

• Rhabdomyosarcoma

• Non-rhabdomyosarcoma

• Soft tissue primitive neuroectodermal tumor (PNET)

• Extraosseous Ewing's sarcoma

PATIENT CHARACTERISTICS:

Age:

• Under 18

Performance status:

• Not specified

Life expectancy:

• Not specified

Hematopoietic:

• Not specified

Hepatic:

• Not specified

Renal:

• Not specified

PRIOR CONCURRENT THERAPY:

Biologic:

• Not specified

Chemotherapy:

• Not specified

Endocrine:

• Not specified

Radiotherapy:

• Not specified

Surgery:

• Prior primary surgery allowed

Other:

• No other prior therapy