Overview

Surgical Ovarian Drilling Versus Hormonal Treatment for Infertility Associated to PolyCystic Ovaries Syndrome (PCOS)

Status:
Unknown status

Trial end date:
2011-10-01

Target enrollment:

Participant gender:

Summary

PolysCsytic Ovaries Syndrome (PCOS) is the most frequent endocrinopathy. The first stage of infertility treatment is Clomiphene Citrate which leads to 50 % pregnancies. In case of failure, it is possible to propose surgical ovarian drilling or ovarian hyperstimulation with Intra Uterine Insemination (IUI) which lead to 50% pregnancies each. However, surgical treatment could be associated to surgical complications, and medical treatment could be associated to ovarian hyperstimulation syndrome and/or multiple pregnancies. The aim of this study is to compare the two treatments to demonstrate the equivalence of efficacy and the diminution of multiple pregnancies by the surgical treatments. After an ambulatory surgery we will observe the spontaneous fertility during 9 months. For the medical treatment, Metformin is proposed during 9 months associated with 3 cycles of ovarian hyperstimulation and IUI if the sperm is normal

Phase:

Phase 4

Details

Lead Sponsor:

Assistance Publique - Hôpitaux de Paris

Collaborators:

Centre Hospitalier Universitaire, Amiens
CMCO SIHCUS, Schiltingheim
Hopital Antoine Beclere
Hôpital Jean Verdier
Jean Rostand Intercommoned Hospital
Lille Hospital : Jeanne de Flandre Hospital
Strasbourg Hospital : Civil Hospital
Study and research center of sterility (Lyon)
University Hospital, Caen
University Hospital, Clermont-Ferrand
University Hospital, Strasbourg, France

Treatments:

Metformin