This study is a prospective, multi-institutional, noninferiority, randomized control trial
that will compare the efficacy of two antibiotic treatments in preventing SSI in patients
receiving immediate breast reconstruction with tissue expanders (TE-BR). The patients will be
randomly assigned to one of the two treatment groups. One group will receive a single dose of
antibiotics just before surgery and if necessary, more doses during the surgery. The other
group will receive the same treatment as the first group, along with an additional week of
antibiotics after surgery. The study will assess the rates of SSI from the two groups. It
will also assess the type, duration and method (oral vs. intravenous) of subsequent
antibiotic use for patients who develop SSIs in each group.