Surgical Site Infections After Liver Transplantation Based on Perioperative Antibiotics

• Status: Completed
• Trial end date: 2015-10-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will be to prospectively determine differences in Surgical Site Infection (SSI) if a prolonged course of post-operative antibiotics are used following liver transplantation.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Institute of General Medical Sciences (NIGMS); University of Virginia
• Collaborator: National Institute of Allergy and Infectious Diseases (NIAID)
• Treatments: Anti-Bacterial Agents; Antibiotics, Antitubercular; Liver Extracts; Piperacillin, tazobactam drug combination

Criteria

Inclusion Criteria:

• All patients ≥ 18 years of age.

• Eligible for liver transplantation by UVA standard protocol.

• First-time transplantation.

• No active infections - requiring antibiotics - excluding antifungals.

Exclusion Criteria:

• All patients < 18 years of age.

• Previous liver transplantation.

• Active infections - requiring antibiotics.

• Allergy to all standard peri-operative antibiotics (piperacillin/tazobactam or UVA standard alternatives for Penicillin allergic patients: ciprofloxacin and vancomycin).