Sustained Mood Improvement With Laughing Gas Exposure: A Randomized Controlled Pilot Trial
Status:
Not yet recruiting
Trial end date:
2023-10-01
Target enrollment:
Participant gender:
Summary
The purpose of the study is to investigate a short-term treatment option for major depressive
disorders by administering nitrous oxide gas. At this time, the main purpose is to complete a
feasibility study with 40 participants suffering from treatment-resistant depression.
Participants will be randomized to (1) Study group: Nitrous oxide (inhaled) + solution of
saline (injected) and the (2) Control group: Oxygen (inhaled) + Midazolam (injected) as an
Active Placebo.