Switching From Morphine to Methadone. A Clinical, Pharmacological and Pharmacogenetic Study

• Status: Completed
• Trial end date: 2009-09-01
• Target enrollment: 0
• Participant gender: All

Summary

Cancer patients on morphine for chronic pain, with side effects or unsatisfactory pain relief, will be rotated to Methadone. We will try to find out what is the best methode to rotate, and the equivalent dosage.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Norwegian University of Science and Technology
• Treatments: Methadone; Morphine

Criteria

Inclusion Criteria:

• • Malignant disease.

• On morphine and in need of opioid rotation. (A patient in need of opioid rotation is defined as having insufficient pain control with or without unacceptable side effects from opioids).

• Able to complete the planned assessment schedules.

• Above 18 years of age.

• If out-patient, the patient lives with someone who can observe him/her.

• Given informed consent according to the ethical guidelines.

Exclusion Criteria:

• Not able to read or write in Norwegian

• The patient has participated in a clinical study 4 weeks prior to inclusion