Sympathetic Regulation of Large Artery Stiffness in Humans With ISH
Status:
Recruiting
Trial end date:
2025-12-30
Target enrollment:
Participant gender:
Summary
Stiffening of your blood vessels, particularly the large vessels from your heart (called the
aorta and carotids) you age contributes to the development of cardiovascular disease (CVD)
such as heart attack and stroke. Nerve activity from your brain to your body also increases
with advancing age but it is unknown if this nerve activity contributes directly to the
stiffening on your blood vessels in older adults in addition to high blood pressure.
Therefore, successful completion of the proposed aims will have a significant clinical impact
by identifying if nerve activity from your brain could be a novel target for therapies that
would lower stiffness of the aorta and carotid arteries in older adults.