Sympathetic and Vascular Function in Takotsubo Syndrome

• Status: Completed
• Trial end date: 2023-01-23
• Target enrollment: 0
• Participant gender: Female

Summary

The primary objective of this prospective, observational study is to compare muscle sympathetic nerve activity at rest and during stress between female patients with Takotsubo syndrome and healthy, matched volunteers.

• Do Takotsubo patients have an increased sympathetic nerve activity compared to controls?

• Do Takotsubo patients have an exaggerated sympathetic nerve activity response to stress?

• Does the sympathetic nerve activity response to stress in Takotsubo change after receiving the beta blocking agent metoprolol?

Participants will be examined with muscle sympathetic nerve activity recording in the peroneal nerve at rest and during cold pressor test. After intravenous injection with beta blocking agent (metoprolol) or placebo (saline) in a 1:1 randomized fashion, muscle sympathetic nerve recording at rest and during stress will be repeated.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Danderyd Hospital
• Treatments: Metoprolol

Criteria

Inclusion Criteria:

For patients:

• Diagnosis of Takotsubo cardiomyopathy

For Controls:

• Matching age with Takotsubo patients

• Signed informed consent

Exclusion Criteria:

• Coronary anathomy precluding intracoronary investigations

• Severe obstructive pulmonary disease

• Kidney failure with estimated glomerular filtration rate < 30 ml/min/m2

• Active malignancy

• Pericarditis