Sympathetic and Vascular Function in Takotsubo Syndrome
Status:
Completed
Trial end date:
2023-01-23
Target enrollment:
Participant gender:
Summary
The primary objective of this prospective, observational study is to compare muscle
sympathetic nerve activity at rest and during stress between female patients with Takotsubo
syndrome and healthy, matched volunteers.
- Do Takotsubo patients have an increased sympathetic nerve activity compared to controls?
- Do Takotsubo patients have an exaggerated sympathetic nerve activity response to stress?
- Does the sympathetic nerve activity response to stress in Takotsubo change after
receiving the beta blocking agent metoprolol?
Participants will be examined with muscle sympathetic nerve activity recording in the
peroneal nerve at rest and during cold pressor test. After intravenous injection with beta
blocking agent (metoprolol) or placebo (saline) in a 1:1 randomized fashion, muscle
sympathetic nerve recording at rest and during stress will be repeated.