Overview

Symptom Assessment for Patients With Gastro-esophageal Reflux Disease Receiving Helicobacter Pylori Eradication

Status:
Unknown status
Trial end date:
2019-09-01
Target enrollment:
0
Participant gender:
All
Summary
Background: Rebound acid hypersecretion and acid-related symptoms after discontinuation of proton-pump inhibitor has been reported in previous studies. In patients with concurrent gastro-esophageal reflux disease and Helicobacter pylori infection, whether eradication of H. pylori will aggravate acid-related symptoms after discontinuation of proton-pump inhibitor (PPI) remains elusive Objective: This study aims to investigate the incidence and severity of acid-related symptoms after discontinuation of proton-pump inhibitor in reflux patients receiving H. pylori eradication Expected result: The investigators will find out the incidence and severity of acid-related symptoms after discontinuation of proton-pump inhibitor in reflux patients receiving H. pylori eradication
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
National Taiwan University Hospital
Treatments:
Amoxicillin
Clarithromycin
Rabeprazole
Criteria
Inclusion criteria:

1. Patients with typical reflux symptoms (heartburn and/or acid regurgitation) validated
by standard questionnaire GerdQ.16

2. Aged >= 20 years old.

3. Willing to receive H. pylori eradication therapy.

Exclusion criteria:

1. Symptomatic reflux patients with high grade erosive esophagitis (LA classification
Grade C and D) or Barrett's esophagus documented by endoscopy.

2. Symptomatic reflux patients with a history of using PPI in recent one month.

3. Subjects with known allergy to PPI.

4. Peptic ulcer disease

5. Cancers of the esophagus, stomach, and duodenum

6. Esophageal or gastric varices

7. Active upper gastrointestinal bleeding within 7 days prior to enrollment

8. Status after total or subtotal gastrectomy

9. Pregnancy

10. Use of anticoagulants or antiplatelets within one week prior to enrollment

11. Subjects with bleeding tendency