Synbiotic Treatment in Crohn's Disease Patients

• Status: Completed
• Trial end date: 2008-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether administration of a synbiotic, comprised on inulin and a bifidobacterial probiotic will colonise the gut wall and down-regulate TNF-alpha and other pro-inflammatory cytokines in the mucosa of Crohn's patients with active disease to reduce mucosal inflammation and induce remission.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Dundee
• Treatments: Sulfalene

Criteria

Inclusion Criteria:

• Crohn's disease of large bowel (+/- small bowel disease)

• 18-79 years old

• stable doses of medications

• CDAI >150, <450

Exclusion Criteria:

• short gut syndrome

• pregnancy

• lactation

• antibiotic therapy in last 3 months

• probiotic therapy in last 1 month

• <18, >79 years old

• CDAI <150 or >450

• indeterminate colitis, ulcerative colitis

• alterations to medications in last 3 months