Synchronization of Follicle Wave Emergence and Ovarian Stimulation

• Status: Completed
• Trial end date: 2010-05-01
• Target enrollment: 0
• Participant gender: Female

Summary

The objective of the study is to elucidate the effect of synchronizing initiation of ovarian stimulation treatment with follicular wave emergence in poor responder patients undergoing IVF/ICSI and ET. We hypothesize that initiating treatment on day 1 versus day 4 of the cycle will increase the number of follicles recruited and oocytes retrieved.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Saskatchewan
• Collaborator: Royal University Hospital Foundation
• Treatments: Cetrorelix

Criteria

Inclusion Criteria:

• Informed consent obtained

• Age of 43 years or younger

• 18 < BMI < 35

• History of poor response to ovarian stimulation as determined by:

• previously cancelled oocyte retrieval procedure due to < 4 follicles greater than 12 mm on ultrasound OR

• < 3 mature oocytes

• Physical exam performed within the past 12 months

• Normal or corrected levels of TSH and Prolactin within the past 12 months

• Has not taken ovarian suppression therapy within 1 month of initiating study drug

Exclusion Criteria:

• Chronic medical conditions such as renal failure

• Documented ovarian failure

• Presence of only one ovary

• Serum Day 3 FSH > 12 IU/L within the past 6 months

• Ovaries inaccessible transvaginally

• Concomitant glucocorticoid use

• Ongoing pregnancy

• Any contraindications to ovarian stimulation treatment

• Participation in an investigational drug trial in the 30 days prior to the pre-study visit