Synergistic Effect Of Parenteral Diclofenac And Paracetamol In The Pain Management Of Acute Limb Injuries
Status:
Not yet recruiting
Trial end date:
2022-08-15
Target enrollment:
Participant gender:
Summary
Acute limb injury is a common reason to visit an emergency department worldwide. Intense pain
related to the injury is always a concern for an emergency physician and requires effective
analgesia within the shortest possible time. Non-steroidal anti-inflammatory drugs (NSAIDs),
opioids and paracetamol are the commonly used drugs in an emergency department. The choice of
analgesia should be established by its efficacy, logistics involved and route of
administration. There is good evidence about NSAIDs being the first line analgesia and
paracetamol is reported to have the narcotic sparing effect, either alone or as an adjunctive
treatment in different settings. The synergistic effect of paracetamol with diclofenac in
acute limb injuries related pain management lacks good- quality evidence. Therefore
investigators proposed a large, well designed, randomized double-blind trial to develop
high-quality evidence. The study aims to assess the efficacy of paracetamol in addition to
diclofenac, and compare the difference between oral and intravenous paracetamol
administration in acute limb injuries in the emergency department.