Synergistic Effect of Ibuprofen and Hydromorphone for Postoperative Pain
Status:
Completed
Trial end date:
2014-07-01
Target enrollment:
Participant gender:
Summary
Intravenous form of ibuprofen is recently approved by FDA and reports are rare on the
co-administration with opioids. The investigators searched whether intravenous
ibuprofen-hydromorphone combination is synergistic, additive, or infra-additive on
postoperative pain using combination index (CI), dose reduction index (DRI) and isobologram.