Synergistic Effect of Ibuprofen and Hydromorphone for Postoperative Pain

• Status: Completed
• Trial end date: 2014-07-01
• Target enrollment: 0
• Participant gender: Female

Summary

Intravenous form of ibuprofen is recently approved by FDA and reports are rare on the co-administration with opioids. The investigators searched whether intravenous ibuprofen-hydromorphone combination is synergistic, additive, or infra-additive on postoperative pain using combination index (CI), dose reduction index (DRI) and isobologram.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Samsung Medical Center
• Treatments: Hydromorphone; Ibuprofen

Criteria

Inclusion Criteria:

• American Society of Anesthesiologists (ASA) physical status І or ІІ who were able to communicate and understand the pain scales

Exclusion Criteria:

• any contraindication to the use of ibuprofen or hydromorphone

• a history of allergy or hypersensitivity

• a calculated creatinine clearance of <75 mL/min

• the presence or history of asthma, bleeding tendency, coronary artery bypass graft (CABG) surgery, heart failure, peptic ulcer disease, inflammatory bowel disease or any other gastrointestinal disorder, and renal or hepatic disease

• pregnancy

• age younger than 18 yr

• intraoperative use of regional anesthesia

• intraoperative administration of analgesics other than remifentanil

• postoperative pain ≤3 on a NRS in the post-anesthesia care unit (PACU)