Systematic Evaluation of Protamine Doze in Cardiac Surgery

• Status: Unknown status
• Trial end date: 2020-02-28
• Target enrollment: 0
• Participant gender: All

Summary

The precise amount of protamine required to neutralize unfractionated heparin (UFH) remains unknown. This study will systematically identify the doze needed to neutralize UFH following cardiopulmonary bypass (CPB).

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Lawson Health Research Institute
• Treatments: Calcium heparin; Heparin; Protamines

Criteria

Inclusion Criteria:

• Elective cardiac surgery patients > 18 years age who can provide written consent for the study.

Exclusion Criteria:

• History of any known coagulopathies, liver dysfunction, previous cardiac surgery, preoperative abnormal coagulation profiles, recent exposure to heparin (unfractionated or low molecular weight), warfarin, clopidogrel or other direct thrombin inhibitors in the preceding 7 days.

• History of heparin resistance

• History of adverse reactions to protamine

• Patients identified as having heparin resistance

• Anticipated CPB time > 2-2.5 hrs